Resveratrol Information
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Resveratrol Information
Resveratrol, 3,5,4'-trihydroxystilbene, a polyphenol, may have varous health
benefits. This article summarizes key information, such as source,
potential health benefits, side effects, toxicity, dosage forms, dose, studies
about resveratrol.
Resveratrol Source / Resveratrol Wine
The major sources of resveratrol are red wine and grapes. However, one
liter of red wine contains only 1.5-3 mg of resveratrol, while some animal
studies suggest intake of 500 mg of resveratrol for its therapeutic effects
on certain conditions. [1,8]
Resveratrol Study / Health Benefits of Reveratrol
In vitro or animal studies, resveratrol exhibits a wide range of biological
effects, such as antiplatelet, anti-inflammatory, anticancer, antimutagenica
and antifungal activities. [1]
Resveratrol Antioxidant
Resveratrol is a potent antioxidant and it is believed to have health benefits
on various conditions such as cancer and cardiovascular diseases. [1]
Resveratrol Cancer
Researchers found that resveratrol inhibits cancer initiation and promotion.
[2,3] In a study, resveratrol causes suppression of DNA synthesis,
activation of nitric oxide synthase in gastric adenocarcinoma cells. [6]
Resveratrol Arthritis
It is believed resveratol may benefit people suffered from arthritis.
Resveratrol Diabetes / Cardiovascular Diseases
Resveratrol may protect and maintain the intact endothelium, exhibits
antiatherosclerotic properties, inhibits the LDL oxidation, suppress the
platelet aggregation and exhibits estrogen like action. [4,7]
Resveratrol Weight
Not sure. If resveratrol has benefits on weight management.
Resveratrol Cream / Resveratrol Skin Cream
Studies show topical applied resveratrol inhibits HSV lesion formation in
the skin of mice. [A]
Resveratrol Dosage / Resveratrol Pill / Resveratrol Cap
Resveratrol is supplemented in pills and capsules. Surfactant is added in
some products to improve the release rate of resveratrol. Resveratrol is
water-insoluble.
Reveratrol Side Effects / Resveratrol Dose
Resveratrol is a metal chelator; it may prevent copper absorption and lead
to copper deficiency. Animal study shows that high dose of resveratrol is
toxic. Though daily dose of 500 mg resveratrol (without surfactant, such as
Tween 80) is promoted, I am not sure if it is safe.
Reference:
[A] Docherty JJ, Smith JS, Fu MM, Stoner T, Booth T. Effect of topically
applied resveratrol on cutaneous herpes simplex virus infections in
hairless mice. Antiviral Res. 2004 Jan;61(1):19-26. [1] Neil E Levin et al,
Pomeratrol™ Fact Sheet, NowFoods Online Publication, September
20, 2005 [2] Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher
CW, et al. chemopreventive activity of resveratrol, a natural product derived
from grapes. Science 1997;275:218-20 [3] Signorelli P and Ghidoni R
Resveratrol as an anticancer nutrient: molecular basis, open questions and
promises. J Nutr Biochem. 2005 Aug;16(8): 449-66. [4] Olas B, Wachowicz
B. Resveratrol, a phenolic antioxidant with effects on blood
platelet functions. Platelets. 2005 Aug;16(5):251-60. [5] Ma ZH, Ma QY
Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol.
2005 Jun 7;11(21):3171-4. [6] Atten MJ, Godoy-Romero E, Attar BM, Milson
T, Zopel M, Holian O., Resveratrol regulates cellular PKC alpha and delta to
inhibit growth and induce apoptosis in gastric cancer cells. Invest New
Drugs. 2005 Mar;23(2):111-9. [7] Dong HH Ren HL New progression in the
study of protective properties of resveratrol in anticardiovascular disease.
Bratisl Lek Listy. 2004;105(5-6):225-9. [8] Phytoalexin, Medfriendly.com
Online Publication, September 20, 2005. [9] Juan ME et al, trans-
Resveratrol, a natural antioxidant from grapes, increases
sperm output in healthy rats. J Nutr. 2005 Apr;135(4):757-60. [10] Bertelli AA
et al, Resveratrol, a component of wine and grapes, in the prevention of
kidney disease. Ann N Y Acad Sci. 2002 May;957:230-8. [11] Wu SL et al,
Resveratrol prolongs allograft survival after liver transplantation in rats.
World J Gastroenterol. 2005 Aug 14;11(30):4745-9. [12] Crowell
JA et al, Resveratrol-associated renal toxicity. Toxicol Sci. 2004 Dec;82(2):
614-9. Epub 2004 Aug 25.
Resveratrol, 3,5,4'-trihydroxystilbene, a polyphenol, may have varous health
benefits. This article summarizes key information, such as source,
potential health benefits, side effects, toxicity, dosage forms, dose, studies
about resveratrol.
Resveratrol Source / Resveratrol Wine
The major sources of resveratrol are red wine and grapes. However, one
liter of red wine contains only 1.5-3 mg of resveratrol, while some animal
studies suggest intake of 500 mg of resveratrol for its therapeutic effects
on certain conditions. [1,8]
Resveratrol Study / Health Benefits of Reveratrol
In vitro or animal studies, resveratrol exhibits a wide range of biological
effects, such as antiplatelet, anti-inflammatory, anticancer, antimutagenica
and antifungal activities. [1]
Resveratrol Antioxidant
Resveratrol is a potent antioxidant and it is believed to have health benefits
on various conditions such as cancer and cardiovascular diseases. [1]
Resveratrol Cancer
Researchers found that resveratrol inhibits cancer initiation and promotion.
[2,3] In a study, resveratrol causes suppression of DNA synthesis,
activation of nitric oxide synthase in gastric adenocarcinoma cells. [6]
Resveratrol Arthritis
It is believed resveratol may benefit people suffered from arthritis.
Resveratrol Diabetes / Cardiovascular Diseases
Resveratrol may protect and maintain the intact endothelium, exhibits
antiatherosclerotic properties, inhibits the LDL oxidation, suppress the
platelet aggregation and exhibits estrogen like action. [4,7]
Resveratrol Weight
Not sure. If resveratrol has benefits on weight management.
Resveratrol Cream / Resveratrol Skin Cream
Studies show topical applied resveratrol inhibits HSV lesion formation in
the skin of mice. [A]
Resveratrol Dosage / Resveratrol Pill / Resveratrol Cap
Resveratrol is supplemented in pills and capsules. Surfactant is added in
some products to improve the release rate of resveratrol. Resveratrol is
water-insoluble.
Reveratrol Side Effects / Resveratrol Dose
Resveratrol is a metal chelator; it may prevent copper absorption and lead
to copper deficiency. Animal study shows that high dose of resveratrol is
toxic. Though daily dose of 500 mg resveratrol (without surfactant, such as
Tween 80) is promoted, I am not sure if it is safe.
Reference:
[A] Docherty JJ, Smith JS, Fu MM, Stoner T, Booth T. Effect of topically
applied resveratrol on cutaneous herpes simplex virus infections in
hairless mice. Antiviral Res. 2004 Jan;61(1):19-26. [1] Neil E Levin et al,
Pomeratrol™ Fact Sheet, NowFoods Online Publication, September
20, 2005 [2] Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher
CW, et al. chemopreventive activity of resveratrol, a natural product derived
from grapes. Science 1997;275:218-20 [3] Signorelli P and Ghidoni R
Resveratrol as an anticancer nutrient: molecular basis, open questions and
promises. J Nutr Biochem. 2005 Aug;16(8): 449-66. [4] Olas B, Wachowicz
B. Resveratrol, a phenolic antioxidant with effects on blood
platelet functions. Platelets. 2005 Aug;16(5):251-60. [5] Ma ZH, Ma QY
Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol.
2005 Jun 7;11(21):3171-4. [6] Atten MJ, Godoy-Romero E, Attar BM, Milson
T, Zopel M, Holian O., Resveratrol regulates cellular PKC alpha and delta to
inhibit growth and induce apoptosis in gastric cancer cells. Invest New
Drugs. 2005 Mar;23(2):111-9. [7] Dong HH Ren HL New progression in the
study of protective properties of resveratrol in anticardiovascular disease.
Bratisl Lek Listy. 2004;105(5-6):225-9. [8] Phytoalexin, Medfriendly.com
Online Publication, September 20, 2005. [9] Juan ME et al, trans-
Resveratrol, a natural antioxidant from grapes, increases
sperm output in healthy rats. J Nutr. 2005 Apr;135(4):757-60. [10] Bertelli AA
et al, Resveratrol, a component of wine and grapes, in the prevention of
kidney disease. Ann N Y Acad Sci. 2002 May;957:230-8. [11] Wu SL et al,
Resveratrol prolongs allograft survival after liver transplantation in rats.
World J Gastroenterol. 2005 Aug 14;11(30):4745-9. [12] Crowell
JA et al, Resveratrol-associated renal toxicity. Toxicol Sci. 2004 Dec;82(2):
614-9. Epub 2004 Aug 25.
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